Dermatology: Vitiligo
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Phusion Pharmacy can compound custom medications for vitiligo for custom Rx compounding. Just call to speak to one of our compounding pharmacists. 401-823-0000.

Pseudocatalase Cream
Vitiligo is a spontaneous irregular depigmentation of skin. Patients with vitiligo have low catalase levels in their epidermis with high levels of hydrogen peroxide. Pseudocatalase cream is an externally applied UVB-activated product that can lead to recovery of the oxidative damage in the epidermis and remarkable repigmentation.
Skin Pharmacol Appl Skin Physiol 1999 May-Jun;12(3):132-8
Successful treatment of oxidative stress in vitiligo. Click here to access the PubMed abstract
J Pathol 2000 Aug;191(4):407-16
Melanocytes are not absent in lesional skin of long duration vitiligo. Click here to access the PubMed abstract
J Investig Dermatol Symp Proc 1999 Sep;4(1):91-6
In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. Click here to access the PubMed abstract
Dermatology 1995;190(3):223-9 Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients. Click here to access the PubMed abstract
Topical Phenylalanine    Melanocytes may still be present in long-standing (>25 years) depigmented skin of patients with vitiligo. L-phenylalanine uptake and turnover in the pigment forming melanocytes is vital for initiation of melanogenesis. Phenylalanine hydroxylase activities increase linearly with inherited skin color yielding eightfold more activities in black skin compared to white skin. 
Camacho and Mazuecos performed an uncontrolled retrospective survey of a group of 193 patients (171 participants after screening) with evolving vitiligo who were treated with oral (50 or 100 mg/kg daily) and topical (10% gel) phenylalanine plus sun exposure . When the study closed, 100% repigmentation was achieved in 122 patients on the face, 35 on the trunk, and 33 on the limbs. Patients who were treated during the months of high solar radiation (and therefore also used the topical phenylalanine) achieved greater repigmentation. No side effects were reported.
Arch Dermatol. 1999;135:216-217
Treatment of vitiligo with oral and topical phenylalanine: 6 years of experience. Click here to access the PubMed abstract
J Drugs Dermatol 2002 Sep;1(2):127-31
Oral and topical L-phenylalanine, clobetasol propionate, and UVA/sunlight--a new study for the treatment of vitiligo. Click here to access the PubMed abstract
Mol Genet Metab 2005 Dec;86(4):27-33
Decreased phenylalanine uptake and turnover in patients with vitiligo. Click here to access the PubMed abstract

Treatment Options for Vitiligo
Please select a topic below to learn more about our pharmacists' abilities to compound custom dermatology products:

Acne

Athlete's Foot

Chemical Peels

Diaper Rash / Incontinence

Head lice / Scabies

Molluscum Contagiosum

Nail Infection / Removal

Pigmentation Abnormalities

Plantar Warts / Warts

Rosacea

Scarring and Keloids

Topical Anesthetics

Sun Protection / Photoaged Skin / Wrinkles

Pruritis

Psoriasis

Vitiligo

Examples of Compounded Medications



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